Understanding Fatigue: Which Biomarkers Can Provide Insight Into Your Energy Levels

Feeling tired is one of the most common concerns people experience in everyday life. Even with sufficient sleep, many still report low energy or reduced concentration. Fatigue is a non-specific signal - it can be influenced by nutrition, lifestyle, stress, physical activity, or how efficiently the body produces and uses energy.

Written by

Aware team

Medically Reviewed by

What are biomarkers?
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A clinical blood test at an Aware partner clinic can help you better understand important biomarkers and gain clarity on which areas of your health may benefit from additional attention. While such tests cannot diagnose or treat medical conditions, they provide insight into biological processes that influence overall well-being.

How Biomarkers Can Provide Orientation‍

Biomarkers are measurable substances in the blood that reflect how the body regulates processes such as oxygen transport, metabolism, hormonal signaling, and cellular energy production. The following biomarkers are well-researched and included in Aware’s test panels, making them helpful indicators when exploring persistent tiredness.

1. Iron Status (Ferritin, Iron, Transferrin)‍

Iron is essential for the production of hemoglobin, which transports oxygen throughout the body. Lower ferritin values indicate reduced iron stores, which research has associated with decreased energy and reduced physical performance.

‍2. Vitamin B12 & Folate‍

These B-vitamins play a key role in red blood cell formation, energy metabolism, and nervous system function. Lower levels are linked in studies to reduced endurance, concentration difficulties, or general fatigue.

‍3. Thyroid Hormones (TSH, Free T3, Free T4)‍

Thyroid hormones influence metabolic rate, temperature regulation, and energy turnover. Variations in TSH or the free hormones can reflect changes in metabolic activity and may help explain shifts in energy levels.

‍4. Glucose & HbA1c‍

These markers provide information about blood sugar balance over time. Fluctuations in glucose availability can affect concentration and perceived energy during the day.

‍5. Vitamin D‍

Vitamin D supports many processes in the body, including immune function and muscle performance. Suboptimal levels have been associated in research with increased perceived fatigue.

‍6. hs-CRP (High-sensitivity C-reactive Protein)‍

hs-CRP reflects systemic inflammatory activity. Higher levels may indicate that the body is under increased physiological strain.

Wie Aware dich unterstützt

Bei Aware wird dein Blut in zertifizierten Partnerlaboren analysiert. Deine Ergebnisse erhältst du übersichtlich in der App – inklusive verständlicher Erklärungen zu deinen Biomarkern und Hinweisen, welche Lebensstilbereiche du dir genauer anschauen könntest.

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Note: Aware tests do not diagnose, prevent, or treat medical conditions. They help you better understand your current biomarker status and support informed conversations with healthcare professionals.

Get clarity on your energy levels: Book your lab test

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